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Modification of H-2 Antigenic Sites by Enzymatic Treatment Influences Virus-Specific Target Cell Lysis¹

From the Hygiene Institut der Universität Göttingen, D-3400 Göttingen, Kreuzbergring 57, W. Germany

Abstract

Vaccinia virus-infected cells were treated enzymatically to remove H-2 antigenic sites. The effect of this procedure on virus-specific cell-mediated cytolysis (CMC) and virus-specific antibody-mediated cytolysis (AMC) was tested. Due to the inhibition of cellular proteinsynthesis by the vaccinia virus infection, H-2 antigenic sites were not resynthesized while there was a continuous production of viral surface antigens.

These cells with a high concentration of viral surface antigens and decreased H-2 determinants could be used as targets in the virus specific AMC. But they were not lysed in the virus specific CMC which emphasizes the significance of H-2 antigens during recognition of virus-specific determinants by T cells.

Footnotes

¹ This work was supported by the Deutsche Forschungsgemeinschaft, D-5300 Bad Godesberg, W. Germany.

² Reprint requests should be sent to Dr. U. Koszinowski, D-3400 Göttingen, Kreuzbergring 57, W. Germany.