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The Genetics of Cell-Mediated Lympholysis¹

From the Departments of Laboratory Medicine and Pathology and Medicine, University of Minnesota Hospitals, Minneapolis, Minnesota 55455, and the Department of Microbiology, Duke University, Durham, N.C. 22706

Abstract

The role of HLA antigens in the generation of cytotoxic cells in CML has been investigated. Cytotoxic effector cells were generated in MLC among HLA-A or HLA-A and HLA-B disparate, HLA-D identical siblings, and among HLA-A and HLA-B disparate, MLC identical (%RR 2 3.6) unrelated individuals. The data indicate that HLA-D differences and poliferative MLC responses as measured by ³H-thymidine incorporation are not requisite for the in vitro generation of cytotoxic cells and suggest the existence of a CML-S locus (loci) distinct from HLA-A, HLA-B and HLA-D. The degree of cytotoxicity generated in a proliferative versus a "nonproliferative" MLC was comparable.

In addition, these studies demonstrate that antigens other than the currently definable HLA-A, HLA-B, HLA-C, and HLA-D can serve as target determinants in cell-mediated lympholysis.

Footnotes

¹ This work was supported in part by United States Public Health Service Grants HL-06314 and AI-12478, and by the Department of Laboratory Medicine and Pathology of the University of Minnesota Hospitals and Medical School.