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The Journal of Immunology, 1976, 117: 1981-1984.
Copyright © 1976 by The American Association of Immunologists, Inc.
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In Vitro Synthesis of Immunoglobulin and Anti-Viral Antibody in Aleutian Disease Viral Infection of Mink1

Lance E. Perryman, Travis C. McGuire and Keith L. Banks

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99163

Abstract

Lymphoid cells from Aleutian disease virus (ADV)-infected and noninfected mink were cultured in vitro and the synthesis of IgM, IgG, and viral-specific antibody measured. Compared to noninfected mink, lymph node cells from mink with Aleutian disease (AD) contained a higher percentage of plasma cells and immunoglobulin-bearing lymphocytes, synthesized significantly more IgG, and produced detectable quantities of ADV-specific antibody. No significant difference in IgM synthesis was observed.

Footnotes

1 This work was supported in part by National Institutes of Health Grants AI-06477 and GM-00414, and General Research Support Grant RR 05465-13.






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