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Evidence for Separate Subpopulations of B Cells Responding to T-Independent and T-Dependent Immunogens¹

Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Portland, Oregon 97201

Abstract

BALB/c spleen cell cultures were double-challenged with optimal doses of TNP-T-independent and TNP-T-dependent immunogens. The anti-hapten response was additive or synergistic in double challenged cultures compared to the response in cultures challenged with either immunogen alone. A high, suppressive dose of either immunogen did not prevent the response to an optimal dose of the second immunogen in the same culture. Spleen cell cultures were also double challenged with combinations of two T-dependent or two T-independent immunogens. Addition or synergy in the anti-hapten response only occurred when the double challenge consisted of a mixture of T-dependent and T-independent immunogens. These results are consistent with the proposed B₁B₂ classification of B cell subpopulations.

Footnotes

¹ This work was supported by Research Grants AM 13173 and CA 12355 from the United States Public Health Service and a grant from the Medical Research Foundation of Oregon.

² Present address: Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201.