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Antibody Response to Lymphoma Antigens in Syngeneic and H-2 Compatible Mice¹

Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

Abstract

The antibody response to immunization with A/J lymphoma L1117 cells by syngeneic A/J mice and by H-2 compatible B10. A mice has been shown to be highly specific for tumor antigens of the lymphoma cells. In both strains the response exhibits a very slow rise in cytotoxic antibody levels reaching a maximum only after 3 months of biweekly injections. It is also unusual in that cytotoxic activity is primarily due to IgM antibodies even after 20 weeks of immunization. The similarity between these characteristics and those reported for "T-independent" antigens suggests that tumor antigens on L1117 cells may be unable to stimulate helper T cells.

Footnotes

¹ This study was supported by grants from the Medical Research Council of Canada (MA4795), National Cancer Institute of Canada, and the National Institutes of Health (CA 13192), Bethesda, Maryland.

² Recipient of a University of Manitoba Graduate Fellowship.

³ This work was done in partial fulfillment of the requirements for the Ph.D. of J. G. Dalton at the University of Manitoba. Present address: Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

⁴ Scholar of the Medical Research Council of Canada.