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The Journal of Immunology, 1976, 117: 1684-1687.
Copyright © 1976 by The American Association of Immunologists, Inc.
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Abnormalities of Cellular Immune Response in Arthritis Induced by Rubella Vaccination1

Yasuo Chiba, Esmaeel Sadeghi and Pearay L. Ogra2

From the Departments of Pediatrics and Microbiology, State University of New York at Buffalo, and Division of Clinical Infectious Disease and Virology, Children's Hospital, Buffalo, New York 14222

Abstract

The rubella-specific antibody, activity the levels of immunoglobulins and complement in the serum, the number of T cells, and the nature of cell-mediated immunity as measured by lymphocyte transformation (LTF) of circulating lymphocytes in response to rubella virus and phytohemagglutinin (PHA) were studied in 15 children who manifested arthralgia or arthritis after parenteral immunization with HPV-77 DE/5 or RA27/3 live attenuated rubella virus vaccines. Eighteen appropriately matched subjects who developed no post-vaccine complications were included as controls. The immunoglobulins, complement, and rubella antibody levels were similar in all subjects. Although significant rubella specific cell-mediated immunity was detectable in most control subjects, the activity was markedly depressed in subjects with arthritis. The LTF activity in response to PHA was approximately equal in both groups. These findings suggest a selective depression of cell-mediated immunity to rubella virus in subjects with arthritis associated with rubella vaccination.

Footnotes

1 These studies were supported by Grant AM17050-02 from the National Institute of Arthritis, Metabolism and Digestive Diseases and by Henry and Bertha R. Buswell Foundation.

2 Address Reprint requests to: Dr. Ogra, Children's Hospital, 219 Bryant Street, Buffalo, New York 14222.






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