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Ontogeny of the Antibody-Forming Cell Line in Mice

II. Maturation of B Cells During Fetal Development

From the Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T. 2601, Australia

Abstract

This paper maps the developmental stage reached by B cells in mouse fetuses of different ages. The "maturity" of these cells was assessed in a functional way by measuring the time taken for cells to generate antibody-forming progeny when injected into carrier-primed irradiated adult hosts and challenged daily with antigen. A steady uninterrupted progression in development of B cells occurred between 13 days of gestation and birth. There was no evidence for a stage during which B cells could only be paralyzed and not induced by antigen.