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Mapping of the Genetic Control of Murine Response to Low Doses of the Dinitrophenyl Conjugates of Ovomucoid and Bovine -Globulin¹

From the Department of Medicine, Division of Immunology, Stanford University School of Medicine, Stanford, California 94305

Abstract

The antibody responses in mice to low doses of the DNP-conjugates of ovomucoid (OM) and bovine -globulin (BGG) were measured for a number of inbred strains carrying independent and recombinant H-2 haplotypes. This permitted mapping the gene(s) controlling the response to low doses of OM (Ir-l-OM) within the I-A subregion of the H-2 complex. Similarly, it was possible to map the primary gene(s) controlling the response to low doses of BGG (Ir-l-BGG) within the I-A and/or I-B subregions. Further localization of the Ir-l-BGG gene(s) to the I-A or I-B subregion of the H-2 complex was not possible due to the ambiguous response of the B10.A(4R) strain of mice.

Footnotes

¹ This research was supported by United States Public Health Service Research Grant AI-07757.

² J. H. F. was the recipient of Postdoctoral Fellowship DRF-541 from the Damon Runyon Memorial Fund for Cancer Research. His present address is: Department of Biophysics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205.