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Regulatory Effect of Interferon on T Cells in Vitro¹

Institute of Medical Microbiology, University of Aarhus, DK-8000 Aarhus C, Denmark, and the Central Public Health Laboratory and Finnish Red Cross Blood Transfusion Service, Helsinki, Finland

Abstract

Purified human lymphocyte interferon (PIF) was added to mixed lymphocyte cultures; DNA synthesis was measured and killer-cell generation was determined. At certain concentrations, PIF inhibited proliferation, but at the same time increased the killer efficiency of the resultant culture cells. It is suggested that lymphokines, apart from their normal mediator function, may play a role as regulators of the generating immune response.

Footnotes

¹ This work was supported by the Danish Cancer Society and "Fonden til l gevidenskabens fremme".

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