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The Journal of Immunology, 1976, 117: 1295-1299.
Copyright © 1976 by The American Association of Immunologists, Inc.
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Mixed Lymphocyte Reactions: Augmentation by Drugs That Inhibit Stimulator Cell Protein Synthesis1

Charles M. Metzler, Thomas G. Kostyk and Richard K. Gershon

Yale University School of Medicine, Department of Pathology, New Haven, Conecticut 06510

Abstract

Inhibiting the protein synthesis of F1 stimulator cells in a mixed lymphocyte reaction (MLR) can enhance the DNA synthetic response and cytotoxic activity of the responder parental lymphocytes, independent of the number of stimulator cells used. Thus stimulator lymphocytes act not only as a source of antigen but play an additional regulatory role in the MLR.

Footnotes

1 This work was supported by an United States Public Health Service Grant Ca-14216 from the National Cancer Institute and by Research Contract CB 43865 from the National Cancer Institute.






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