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Reaginic Antibody Formation in the Mouse

VIII. Depression of the Ongoing IgE Antibody Formation by Suppressor T Cells¹

Department of Medicine, The Johns Hopkins University School of Medicine at the Good Samaritan Hospital, Baltimore, Maryland 21239

Abstract

The ongoing IgE antibody formation against ovalbumin (OA) in high responder mice was depressed by i.v. injections of either native or urea-denatured ovalbumin (UD-OA). Adoptive transfer experiments to determinethe helper function of spleen cells from the treated animals showed that helper function for both IgE and IgG antibody responses diminished after treatment. Evidence was obtained that treatment suppressed the expansion of IgE-B memory cells. When the same treatment with OA or UD-OA was given to OA-primed mice before the appearance of IgE antibody in their serum, OA-specific splenic suppressor T cells were demonstrable. Thus, the transfer of splenic T cells from treated mice into normal mice suppressed the primary IgE and IgG antibody responses of the recipeints to DNP-OA. It was also found that the transfer of the splenic T cells from UD-OA-treated mice into OA-primed mice depressed ongoing IgE antibody formation in the recipients. The results suggested strongly that the decrease of helper function and the depression of ongoing IgE antibody formation by repeated injections of UD-OA was caused by generation of antigen (OA)-specific suppressor T cells.

Footnotes

¹ This work was supported by Research Grant AI 11202 from the U.S. Public Health Service and a grant from the John A. Hartford Foundation, Inc. This paper is publication No. 236 from the O'Neill Laboratories at the Good Samaritan Hospital.

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