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Distinct Target Determinants on Two Lymphoblastoid Lines Derived from the Same Individual¹

Department of Surgery, School of Medicine, University of California, Los Angeles, California 90024

Abstract

Specifically cytotoxic cells were generated in unidirectional mixed leukocyte culture against both T and B lymphoblastoid cell lines. The cytotoxicity observed included both specific and less selective components which were differentiated by the interaction analysis based on the two-way analysis of variance. The results indicate that a T cell line and a B cell line derived from the same person possessed distinct target specificities. The antigens detected by direct cytotoxicity were confirmed by inhibition studies with competitor cells.

Footnotes

¹ This work was supported in part by Contract NO1 CP 43211, within the Virus Cancer Program of the National Cancer Institute.