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Early and Late Contact Sensitivity Reactions in Guinea Pigs Sensitized to Oxazolone

Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland 20014, and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Inbred strain 2 and random-bred guinea pigs injected with oxazolone in incomplete or complete Freund's adjuvant showed contact reactions within an hour after topical application when tested 3 weeks post-sensitization. The time for appearance of skin reactions at 5 days post-sensitization was 8 to 24 hr, more along classic delayed-type hypersensitivity lines. Immune serum harvested several weeks after sensitization was effective for passive transfer of early skin reactivity, while serum at 5 to 10 days was not. Lymph node cells taken 5 days after sensitization of donors could transfer only the late skin reactivity to histocompatible recipients; lymph nodes taken at 15 days did not contain cells capable of such transfers. The heterogeneity of mechanisms involved in the production of contact dermatitis suggested by these results provides new approaches to studies in this area of allergy research.

Footnotes

¹ Bureau of Biologies, Food and Drug Administration.

² National Institute of Allergy and Infectious Diseases.