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Genetic Control of the Immune Response in Rats to the Known Sequential Polypeptide (Tyr-Glu-Ala-Gly)_n

I. Antibody Responses¹

Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 and the Department of Pathology, Immunobiology Research Unit, University of Pennsylvania, Philadelphia, Pennsylvania 19174

Abstract

In inbred rats, the antibody response to the known sequential polypeptide (Tyr-Glu-Ala-Gly)_n (T-G-A-Gly)_n is under the control of two independently assorting loci; (co) dominant, Ag-B-linked Ir-(T-G-A-Gly) I, controlling qualitative responsiveness, and a non-Ag-B-linked modifier locus termed Ir-(T-G-A-Gly) II, controlling the level of antibody produced. The antibody response to (T-G-A-Gly)_n was solely IgG and the level of antibody produced was dependent upon Ir-(T-G-A-Gly) II for phenotypic response type.

Footnotes

¹ This research was supported by National Institutes of Health Research Grants AI 07825, AI 10961, CA 15822, and American Cancer Society Grant IM-5E.

² To whom reprint requests may be addressed.