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The Suppressive Effect of Interferon on the Ability of Mouse Spleen Cells Synthesizing IgE to Sensitize Rat Skin for Heterologous Adoptive Cutaneous Anaphylaxis¹

Department of Microbiology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7

Abstract

Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA.² When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD₅₀ units of interferon reduced HACA reactions by more than 50%; 600 units gave complete inhibition. Interferon may act by inhibiting IgE synthesis and/or release.

Footnotes

¹ This work was supported by the Medical Research Council of Canada.

² Abbreviations used in this paper: RAFC, reaginic antibody forming cells; Ov, ovalbumin; (Al-P-Ov), alum-precipitated pertussis antigen and Ov; PCA, passive cutaneous anaphylaxis; HACA, heterologous adoptive cutaneous anaphylaxis; PRD₅₀, plaque reduction dose 50%; NDV, Newcastle disease virus; VSV, vesicular stomatitis virus; NRS, normal rabbit serum.