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Antibody-Induced Killing in Vivo of L1210/MTX-R Cells Quantitated in Passively Immunized Mice with ¹³¹I-Iododeoxyuridine-Labeled Cells and Whole-Body Measurement of Retained Radioactivity¹

Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111

Abstract

The killing of the LR subline of the DBA/2J leukemia L1210/MTX by passive antibody was followed in vivo with ¹³¹I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity. The in vivo killing of LR cells was proportional to the in vitro 2-mercaptoethanol resistant titer, independent of the complement system, and radioresistant. Although a large percentage of the leukemic cells was killed in passively immunized mice, the protective effect of the passive antiserum was dependent on the active immune response of the host.

Footnotes

¹ This investigation was supported by Public Health Service Research Grant 5 RO1 CA 14409 from the National Cancer Institute and by the American Cancer Society, Massachusetts Division, Inc. Grant 1418-C-1.

² Department of Immunology and MRC Transplantation Unit, the University of Alberta, Edmonton, Alberta, Canada 26G 2E1. This work is in partial fulfillment for the degree of Doctor of Philosophy.

³ Department of Physiology, Tufts University School of Medicine, Boston Massachusetts 02111.