HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tsai, C.-M. Articles by Ginsburg, V. Search for Related Content PubMed Articles by Tsai, C.-M. Articles by Ginsburg, V.

A Human Cold Agglutinin Which Binds Lacto-N-NeoTetraose

National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Naval Medical Research Institute, Bethesda, Maryland 20014

Abstract

A human cold agglutinin (McC) has been isolated from the serum of a patient with Waldenström's macroglobulinemia by affinity chromatography with a column of glutaraldehyde-fixed erythrocyte stroma mixed with celite. The agglutinin, which is an IgM , reacts weakly with normal adult erythrocytes and strongly with cord cells as well as with adult O_h and O_l cells. The reactivity of all cell types tested was increased to approximately the same level by treatment of the cells with ficin. Inhibition studies indicate the agglutinin is specific for the nonreducing terminal carbohydrate sequence Gal1-4GlcNAc1-3Gal....