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Neonatal Infection with Mouse Thymic Virus

Differential Effects on T Cells Mediating the Graft-versus-Host Reaction

Microbiological Associates, Inc., Bethesda, Maryland 20014, and the Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Neonatal infection with mouse thymic virus (TA), a murine herpes virus, produced extensive but temporary necrosis of the thymus which was maximal at 10 to 14 days of age. Studies of precursor and amplifier cells mediating graft-vs-host (GVH) reactivity of thymocytes, spleen cells (SC), and lymph node cells (LNC) of normal and TA-infected mice were made at 4 and 8 weeks of age. Infection with TA resulting in a profound reduction (70 to 80%) in the direct GVH reactivity of thymocytes at both ages; by comparison, the capacity of thymocytes to produce synergy when combined with normal LNC was normal at 8 weeks. Direct GVH reactivity of SC was depressed 90% 4 weeks after infection with TA but returned to near normal at 8 weeks. Direct GVH reactivity of LNC from TA-infected mice was normal at 4 and 8 weeks of age, but amplifier T cell activity in LNC was markedly depressed at 8 weeks. These results demonstrate that TA has highly selective effects upon subpopulations of T cells in thymus and lymph node.

Footnotes

¹ Present address: Department of Pathology, Box 817, Virginia Commonwealth University, Medical College of Virginia, MCV Station, Richmond, Virginia 23298.

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