HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kermani-Arab, V. Articles by Leslie, G. A. Search for Related Content PubMed Articles by Kermani-Arab, V. Articles by Leslie, G. A.

Structure and Biologic Functions of Human IgD

X. Enhancement of PHA Responsiveness by anti--Activated Lymphocytes¹

Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Portland, Oregon 97201 and the Surgical Research Laboratory, Veterans Administration Hospital, Portland, Oregon 97207

Abstract

Human peripheral lymphocytes with the capacity to be stimulated by anti- exhibited in PHA responsiveness when cultured with anti- 1 or 12 hr before PHA exposure over cells exposed to PHA alone. When these lymphocytes were preincubated with PHA 1 or 12 hr before anti- activation, no augmentation of the PHA response was seen. In addition, lymphocytes from donors with a high PHA response (low anti- activation) failed to show an enhancing effect on PHA responsiveness when pretreated with anti-. Moreover, anti-µ showed no synergistic effect on PHA responsiveness. This study is the first to indicate that anti--activated cells enhance PHA responsiveness.

Footnotes

¹ This research was supported by Grant AI12273 from the National Institutes of Health, a grant from the John A. Hartford Foundation, Inc., and Project 648-1164-01 from the Veterans Administration Hospital, Portland, Oregon 97207.