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Cross-Reactive T-Cell Antigens among Mammalian Species¹

Department of Surgery, Pediatrics, Microbiology, and the Spain Immunology Laboratory, University of Alabama School of Medicine, Birmingham, Alabama 35294

Abstract

Fluoresceinated heteroantisera prepared against T cells of rats, monkeys, and humans were reacted with thymus and spleen cells from 11 selected species. These reagents recognized cross-reacting T cell antigen(s) among rodent species (mouse, rat, guinea pig, and hamster) and among primate species (monkey and humans). With one exception, the cross-reactivity was restricted to a phylogenetic order. All three antisera required relatively few absorptions to achieve T cell specificity for related species when compared to absorption requirements for the isologous species. Differentiation antigens within a phylogenetic order thus appear to be more homologous than other cell surface constituents on T cells.

Footnotes

¹ This study was supported by Grants CA 16673 and CB-23882 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland.