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Regulation of the Immune System by Synthetic Polynucleotides

VI. Amplification of the Immune Response in Young and Aging Mice¹

Department of Microbiology, University of Michigan, Ann Arbor, Michigan 48109

Abstract

Model systems for study of the action of adjuvants in immunodeficient states were developed in 10- to 14-day-old BALB/aj mice and aging BALB/aj mice (12 to 16 months). With sheep red blood cells as antigen polyadenylicpolyuridylic acid complexes (poly A:U) were found to be stimulatory in both the neonatal and aging mice. The effect of poly A:U was similar to that seen when 5 x 10⁵ thymocytes from immunologically mature mice were given with antigen. Cell-free supernatant fluids induced by incubation of poly A:U with thymocytes likewise were capable of restoring the number of antibody-forming cells to normalcy in aging mice.

Footnotes

¹ This work was supported by United States Public Health Service Grant AM 14273.

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