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Cross Reactivity of Human ₂-Microglobulin with Human Granulocyte Colony-Stimulating Activity¹

Ontario Cancer Institute and Departments of Medical Biophysics and Medicine, University of Toronto, Toronto, Canada M4X 1K9

Abstract

Effects of antisera to human ₂-microglobulin (₂m) on factors able to stimulate colony formation in culture by human granulopoietic progenitor cells were investigated. The colony-stimulating activity (CSA) present in media conditioned by cultures of human peripheral leukocytes was suppressed by treatment with anti-₂m. This inhibition was not due to a direct effect on the granulopoietic progenitor cells; controls to test for cytotoxicity and for noncytotoxic inhibition of the progenitor cells by anti-₂m yielded negative results. These experiments provide evidence for a relationship between human CSA and -microglobulin, and suggest a possible analogy between molceules involved in the in vitro regulation of granulopoiesis and products of the major histocompatibility gene complex.

Footnotes

¹ This work was supported by the Ontario Cancer Treatment and Research Foundation (Grant 236), the National Cancer Institute of Canada and the Medical Research Council of Canada (Grant MT-1420).