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Low Molecular Weight Immunoglobulins in Rana Catesbeiana Tadpoles¹

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Abstract

Rana catesbeiana tadpoles formed high and low m. w. antibodies in response to immunization with a bacteriophage. Although the neutralizing activity associated with the low m. w. immunoglobulins was relatively weak, the existence of antibodies in this class was clearly demonstrated by radioimmunoelectrophoresis. Moreover, two antigenically distinct variants of the low m. w. antibodies were detected. These were serologically indistinguishable from the two types of low m. w. immunoglobulin previously isolated from the serum of adult frogs of this species.

Footnotes

¹ This investigation was supported by Grant AI-08054 from the National Institutes of Health. A portion of the work was presented at the 58th annual meeting of the Federation of American Societies for Experimental Biology, April 7–12, 1974 (Abstract No. 2971).

² To whom correspondence should be addressed.