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Immunosuppression of Experimental Autoimmune Myasthenia Gravis by Hydrocortisone and Azathioprine¹

From the Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

Abstract

Experimental autoimmune myasthenia gravis (EAMG), induced in rabbits by injection of acetylcholine receptor (AChR) from Torpedo californica, was suppressed by appropriate treatment with hydrocortisone or with azathioprine. Administration of hydrocortisone in gradually increasing doses, starting at the time of immunization with the receptor, prevented exacerbation of the disease in the early stages of treatment, as was the case when hydrocortisone was administered in high doses from the beginning. Prolonged administration of the antimetabolite azathioprine (Imuran) prevented the appearance of EAMG, for at least 4 months, in rabbits immunized with AChR. Cell-mediated immunity to AChR was demonstrated to be significantly decreased in such treated animals.

The effects of hydrocortisone and azathioprine on EAMG support the view that the disease involves an immunologically cell-mediated mechanism and indicate that the experimental disease can serve as a useful model for chemotherapy of the human disease.

Footnotes

¹ This research was supported in part by a grant from the Chief Scientist's Bureau, Ministry of Health, Israel.

² Present address: Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.

³ To whom correspondence and reprint requests should be sent.