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The Inhibition of Cutaneous Basophil Hypersensitivity Reactions by a Heterologous Anti-Guinea Pig T Cell Serum¹

From the Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111

Abstract

Systemic treatment with a heterologous anti-T cell serum of guinea pigs immunized with EA in IFA markedly suppressed CBH reactivity to specific antigen and T cell mitogens, as judged by gross reactivity, histology, and skin histamine. The antiserum produced a marked drop in circulating lymphocytes, mainly at the expense of T cells, as indicated by the ability of surviving lymphocytes to rosette with rabbit RBC.

It was postulated that the suppression of CBH reactivity is due to the depletion of T cells, which would have released a factor chemotactic for basophils. The data therefore provide further evidence that cutaneous reactions rich in basophils are primarily dependent on a population of T cells.

Footnotes

¹ This study was supported by United States Public Health Service Grant AI 10895.

² In partial fulfillment of the requirements for the Doctor of Philosophy Degree from Tufts University, Medford, Massachusetts 02155.