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The Journal of Immunology, 1976, 116: 1539-1546.
Copyright © 1976 by The American Association of Immunologists, Inc.
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Defining the Heterogeneity of Anti-Tumor Antibody Responses1

Gary P. Segal and Norman R. Klinman2

From the Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19174

Abstract

Studies were undertaken to analyze the humoral in vivo and in vitro antibody response of BALB/c mice to a syngeneic MSV-induced tumor cell line. With a sensitive radioimmunoassay, sera obtained from individual progress or and regressor mice were shown to vary greatly in total tumor-specific antibody concentration as well as immunoglobulin class distribution of the antibody, but no significant difference existed between the groups of progressor and regressor mice as a whole. In addition, serum antibodies from all animals were shown to have extensive cross-reactivity against a variety of cell lines chosen to share one or more antigens with the cell line used for immunization. Conversely, when in vitro fragment cultures of splenic tissue from progress or and regressor mice were stimulated with tumor-related antigen, differences in responsiveness among normal, progressor, and regressor mice were observed. In addition, antibodies derived from fragment cultures displayed several different cross-reactivity patterns all of which were more restricted in specificity than serum antibodies.

Footnotes

1 This work was supported by United States Public Health Service Grant CA-15822 from the National Cancer Institute.

2 Recipient of Public Health Service Career Development Award 1-K04-A1-33983 from the National Institutes of Allergy and Infectious Diseases.






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