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The Journal of Immunology, 1976, 116: 1520-1525.
Copyright © 1976 by The American Association of Immunologists, Inc.
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Cell-Mediated Immune Response to Herpes Simplex Virus: Type-Specific Lymphoproliferative Responses in Lymph Nodes Draining the Site of Primary Infection1

Robert P. Jacobs2, Laure Aurelian and Gerald A. Cole3

From the Department of Epidemiology, School of Hygiene and Public Health and Departments of Medicine and Laboratory Animal Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205

Abstract

Cell-mediated immune responses to type 1 and type 2 HSV were studied in rabbits using an in vitro lymphocyte transformation assay. The footpad route of inoculation was used to allow us to study the specificity and degree of localization of the responses. Rabbits inoculated in the hind footpads with infectious HSV-I or HSV-II mount typespecific lymphocyte transformation responses that are localized to draining lymphoid organs. Type-specificity requires careful control of all in vitro culture conditions and reflects the extensive cross-reactivity demonstrated by serologic techniques. While lymphocyte transformation responses can be detected with immune SL and PBL, presumably the result of early escape of antigen into the systemic circulation, responses by draining LNL are significantly greater in magnitude. Distant LNL have not been shown to respond. It is postulated that the augmented local immune response to HSV plays a significant role in controlling recurrent HSV infections.

Footnotes

1 This work was supported in part by Contract NO-1-CP-43330 within the Virus Cancer Program, National Cancer Institute.

2 Recipient of an Arthritis Foundation Postdoctoral Fellowship.

3 Recipient of Research Career Development Award NS-46242 from the National Institute of Neurological and Communicable Diseases and Stroke.






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