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Antibody against the Antigen Receptor of a Plasmacytoma Prolongs Survival of Mice Bearing the Tumor¹

From La Rabida-University of Chicago Institute and the Department of Pathology, University of Chicago, Chicago, Illinois

Abstract

A transplantable plasmacytoma, TEPC-15 in BALB/c mice, induces a transient antibody response directed against the combining region of the myeloma protein produced by the tumor. Mice immunized with mitomycin-treated tumor cells produce similar antibody but do not develop tumor; mice so immunized survive longer than untreated mice when inoculated with viable TEPC-15 cells. This protection afforded by immunization can be transferred by serum alone; the protective effect of passively given serum is eliminated by absorbing out antibody directed against the myeloma protein.

Footnotes

¹ This research is dedicated to the Max Goldenberg Foundation for its generous help. This work was supported by United States Public Health Service Grants A1-10242, A1-12235 and National Cancer Institute CB 43998.

² P.G.B. is a MSTP Trainee supported by United States Public Health Service Grant 2T056MO 1939-06.

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