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Increased Iodine Uptake by Obese Strain Thyroid Glands Transplanted to Normal Chick Embryos¹

From the Institute for General and Experimental Pathology, University of Vienna, Waehringer Strasse 13, A-1090 Vienna, Austria

Abstract

The Obese strain (OS) of chickens spontaneously develops autoimmune thyroiditis. Since a defect or abnormality of the thyroid gland may be involved in this disease experiments were performed to compare the iodine uptake of OS with normal thyroid glands. To minimize the interaction of the OS immune system with the thyroid gland during these studies, thyroids were removed from 16-day-old embryos and transferred to the chorioallantoic membrane (CAM) of 9-day-old normal White Leghorn (NWL) embryos. NWL thyroid glands were transferred to the same CAM. Six days later the 20-hr ¹³¹I uptake of the transplants was determined. Twenty OS thyroid lobes had a mean ¹³¹I uptake of 2960 ± 740 cpm, whereas the NWL thyroids incorporated significantly less iodine (890 ± 160 cpm; p < 0.025). These results, along with a previous report suggest that an abnormality of the thyroid gland might be an important factor in the development of autoimmune thyroiditis.

Footnotes

¹ This work was supported by a grant from the Austrian Research Council (Project 1997).

² Recipient of a postdoctoral Research Fellowship of the Austrian Research Council.

³ Present address: Department of Immunology and Microbiology, Wayne State University, 540 E. Canfield Avenue, Detroit, Michigan 48201.

⁴ Present address: Institute for General and Experimental Pathology, University of Innsbruck. Schöpfstr. 41, A-6020 Innsbruck, Austria.

This article has been cited by other articles:

				G. WICK, R. SGONC, and O. LECHNER Neuroendocrine-Immune Disturbances in Animal Models with Spontaneous Autoimmune Diseases Ann. N.Y. Acad. Sci., May 1, 1998; 840(1): 591 - 598. [Abstract] [Full Text] [PDF]

				N Bagchi, T. Brown, E Urdanivia, and R. Sundick Induction of autoimmune thyroiditis in chickens by dietary iodine Science, October 18, 1985; 230(4723): 325 - 327. [Abstract] [PDF]