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Studies on the Terminal Stages of Antibody-Complement-Mediated Killing of a Tumor Cell

II. Inhibition of Transformation of T* to Dead Cells by 3'5' CAMP

From the Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Transformation of T* to dead cells was prevented by 3'5' cAMP. The effect of 3'5' cAMP was dose, time, and temperature dependent. T* washed free of 3'5' cAMP after short-term incubation proceeded to die to the same extent as control cells. After 3 hr of incubation of T* with 3'5' cAMP the level of killing was significantly reduced. The 3'5' cyclic nucleotides of uridine, guanine, cytosine, and thymidine and the 2'3' cyclic adenosine nucleotide were not effective. It was concluded that prolonged treatment of T* with 3'5' cAMP either irreversibly blocked the damage-producing process or facilitated the repair of damaged sites.