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The Journal of Immunology, 1976, 116: 1272-1275.
Copyright © 1976 by The American Association of Immunologists, Inc.
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Studies on the Terminal Stages of Antibody-Complement-Mediated Killing of a Tumor Cell

I. Evidence for the Existence of an Intermediate, T*

Michael D. P. Boyle, Sarkis H. Ohanian and Tibor Borsos

From the Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The mechanism of the terminal steps in the lysis of antibody-sensitized tumor cells by complement (TAC) was studied. It was shown that once complement has reacted, lysis proceeded even in the absence of fluid-phase complement. Transformation of TAC to dead cells was found to be at least a two-step process: one of the steps was temperature dependent whereas the other was reversibly inhibited by EDTA. In analogy to the hemolytic system, TAC has been designated T*.






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