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Effects of C-Reactive Protein on the Lymphoid System

II. Inhibition of Mixed Lymphocyte Reactivity and Generation of Cytotoxic Lymphocytes¹

From the Departments of Immunology, Rush Medical College and Microbiology, University of Illinois at the Medical Center, Chicago, Illinois 60612

Abstract

C-reactive protein (CRP), an acute phase reactant which increases in concentration during inflammation, has been found to bind to human T cells and to inhibit certain of their functions. In the present study CRP was found to display a binding specificity for -bearing cells from mouse peripheral lymphoid tissue but not for thymus cells. CRP inhibited the proliferative response in a similar manner in both murine and human mixed lymphocyte reactions. This inhibition was prevented by the addition of the CRP substrate, pneumococcal C-polysaccharide (CPS), and was not a result of toxicity of CRP for lymphocytes. By contrast the response of spleen lymphocytes to mitogenic Con A concentrations was not altered by CRP. CRP also exerted an inhibitory effect on the in vitro generation of cytolytic T lymphocytes (CL) in mixed lymphocyte reactions of mouse spleen cells. The expression of the cytolytic process by T cells sensitized either in vivo or in mixed lymphocyte cultures was not altered in the presence of CRP. Therefore, CRP appears to influence the inductive phase of the allograft response and perhaps exerts a regulatory effect on cellular immune responsiveness during inflammatory reactions.

Footnotes

¹ This work was supported by Grant AI 12870-01 from the National Institutes of Health and grants from the Illinois Heart Association, the Leukemia Research Foundation, Inc., and the Hunter Trust.

² Recipient of NCI Postdoctoral Fellowship 1 F22 CA03628 IMB.

³ H. G. holds the Thomas J. Coogan, Sr. Chair of Immunology, established by Marjorie Lindheimer Everett.

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