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Induction of Immunologic Tolerance in Nursing Neonates by Absorption of Tolerogen from Colostrum¹

From the Departments of Pharmacology and Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22901

Abstract

Deaggregated human -globulin (DHGG) injected into female mice within 24 hr after delivery of a litter enters the colostrum and is absorbed intact through the intestine by nursing neonates. This absorbed HGG was present in the neonatal circulation at concentrations of 0.3 to 0.6 mg/ml of serum under the experimental conditions used. This absorption of HGG by the nursing neonate resulted in a complete, specific, tolerant state to HGG. This tolerant state was stable upon adoptive cell transfer and could not be abrogated by transfer of normal syngeneic spleen cells.

Footnotes

¹ This work was supported in part by National Science Foundation Grants GB40619 and BMS75-09786 and United States Public Health Service Grant AI10225.

² Present address: Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29401.

³ To whom all correspondence should be sent at the Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia, 22901. Recipient of U.S.P.H.S. Research Career Development Award AI00029.

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