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The Effect of Bordetella Pertussis on the Antibody Response in Mice to Type III Pneumococcal Polysaccharide¹

From the Department of Microbiology and Immunology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203

Abstract

The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. Suppression of the antibody response occurred when pertussis cells were injected at the same time as an optimal immunizing dose of SIII. In contrast, the antibody response to high doses of SIII was enhanced by B. pertussis.

When SIII alone was injected, only 19S antibody was detected. However, when B. pertussis was administered with either optimal or high doses of SIII, 7S as well as 19S antibody against SIII was produced.

Footnotes

¹ This work was presented in part at the Meeting of the Federation of American Societies for Experimental Biology, April, 1973. This work was supported by Grant AI 09683, from the National Institutes of Health.