HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Braley-Mullen, H. Search for Related Content PubMed Articles by Braley-Mullen, H.

Secondary IgG Responses to Type III Pueumococcal Polysaccharide

II. Different Cellular Requirements for Induction and Elicitation¹

From the Division of Immunology and Rheumatology, Department of Medicine, University of Missouri, Columbia, Missouri 65201

Abstract

Mice primed with a thymus- (T) dependent form of Type III pneumococcal polysaccharide (S3), i.e., S3 coupled to erythrocytes (S3-RBC) produce S3-specific IgG antibody after secondary challenge with either S3 or S3-RBC. The production of IgG antibody by mice challenged with S3 was shown to be T independent since secondary responses were enhanced when mice were treated with anti-lymphocyte serum (ALS) at the time of secondary challenge with S3 and T-depleted spleen cells responded as well as unfractionated spleen cells to S3 in an adoptive transfer system. Secondary S3-specific IgG responses in mice challenged with S3-RBC were shown to be T dependent by the same criteria. The results obtained by using S3 as the antigen indicate that IgG-producing B cells (B cells) can recognize and respond to antigen in the absence of helper T cells. On the other hand, T cells were required for the induction of S3-specific memory B cells since mice depleted of T cells by treatment with ALS at the time of priming with S3-RBC failed to produce S3-specific IgG antibody after secondary challenge with either S3 or S3-RBC. Since RBC-specific memory cells were induced in T-deprived mice the results suggest that T cell regulation of IgG antibody production may vary for different antigens.

Footnotes

¹ This work was supported in part by Research Grant AI-506-75 from the United Stated Public Health Service.

² H.M. is supported by a postdoctoral fellowship from the Arthritis Foundation.

This article has been cited by other articles:

				S. R. Elliott, R. D. Kuns, and M. F. Good Heterologous Immunity in the Absence of Variant-Specific Antibodies after Exposure to Subpatent Infection with Blood-Stage Malaria Infect. Immun., April 1, 2005; 73(4): 2478 - 2485. [Abstract] [Full Text] [PDF]