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Effect of Cross-Immunization on Monotypic Antibody Responses to Herpes Simplex Virus Types 1 and 2¹

From the Department of Microbiology, Louisiana State University Medical Center, New Orleans, Louisiana 70112

Abstract

New Zealand White rabbits were immunized subcutaneously with partially purified UV-inactivated preparations of herpes simplex virus (HSV-1 or HSV-2) in complete Freund's adjuvant. After the initial immunizations, designated groups of animals received additional amounts of either HSV-1 or HSV-2 at 35-day intervals. Sera were absorbed with lysates of cells infected with heterotypic virus and the residual monotypic antibodies were detected by ⁵¹Cr-release assay using HSV-infected target cells. A positive correlation was found between the ratio of neutralizing antibodies to HSV-1 and HSV-2 (II/I index) and the content of monotypic antibodies. Results showed that production of monotypic antibodies to HSV-1 and HSV-2, under the conditions employed, was independent of previous exposure to HSV.

Footnotes

¹ This work was aided by a grant from the Cancer Association of Greater New Orleans and Grant IM-38 from the American Cancer Society.