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IgM-Mediated, T Cell-Independent Suppression of Humoral Immunity¹

From the Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 and the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510

Abstract

The immunological unreactive state occurring in (T,G)-A-L nonresponder mice after secondary antigen challenge was investigated. Syngeneic IgM anti-(T,G)-A-L antibody-containing plasma, transferred at the time of the time of primary challenge, induced persistent suppression of autologous specific antibody production. Removal of plasma IgM with goat anti-µ antisera removed the ability of the plasma to suppress. The induction and maintenance of the suppressed state were not different in thymectomized or sham-thymectomized animals. Primed animals subjected to graft-vs-host reaction (GVHR) at the time of secondary challenge switched over to IgG production. Animals suppressed by passive antibody transfer reacted to GVHR, at the time of secondary challenge, with specific IgM but not IgG antibody production.

Transfused normal spleen cells partially abrogated suppression only when (suppressed) hosts had been lethally irradiated. Spleen cells from antigen-plus-antibody suppressed donors, upon transfer to previously normal, syngeneic hosts, were less immunocompetent than spleen cells from untreated donors. These data are consistent with a model of IgM mediated, T cell-independent persistent suppression of humoral immunity.

Footnotes

¹ This work was supported by National Institutes of Health Research Grants AI 11313, CA08593, and AI 10497.

² Reprint requests should be addressed to Dr. Grumet at the American Red Cross-Stanford University Blood Center, 3330 Hillview Ave., Palo Alto, California 94304.