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Temporary Inhibition of Antibody-Dependent, Cell-Mediated Cytotoxicity by Pretreatment of Human Attacking Cells with Ammonium Chloride

From the Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Treatment of lymphoid cell preparations with ammonium chloride buffers to remove contaminating erythroid cells markedly reduced the ability of these cells to function as attacking cells in antibody dependent cell mediated cytotoxicity tests (ADCC). The lymphoid cells, however, retained their ability to adhere to antibody-coated target cells Recovery of function 20 hr after exposure to ammonium chloride suggests a metabolic rather than receptor effect of these salts on the ADCC function of lymphocytes.

Footnotes

¹ Present address: Department of Medicine B., Medical Center of Tel-Aviv-Jaffo, Ichilov Hospital, Wizman Street 6, Tel-Aviv, Israel.

² Present address: Department of Medical Oncology, New England Medical Center, Boston, Massachusetts 02111.

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