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Studies on Tolerance Induction in Vitro

II. Requirements for the Generation and Transfer of Suppressor Cell Activity^1,2,

From the Department of Immunology, The Public Health Research Institute of the City of New York, Inc., New York, New York 10016

Abstract

The induction of specific immunologic tolerance and its transfer has been studied in the in vitro response of unprimed rabbit spleen cells to solubilized phage antigens. Evidence presented shows that only viable cells transfer tolerance and that the responsible cells appear devoid of membrane-bound antigen but are sensitive to anti-thymocyte serum. It appears, therefore, that although the in vitro response to solubilized S-T2 has no demonstrable requirement for T "helper" cells, it is subject to the action of T "suppressor" cells.

Footnotes

¹ This work was supported by Training Grant AI-00408, and Grants AI13180-01 and AI13159-01 from the National Institutes of Health.

² A preliminary report on these studies was presented at the Annual Meeting of the Federation of American Societies for Experimental Biology, April, 1975.

³ Present address: Division of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101. Requests for reprints should be sent to this address.