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Release of Xenotropic Type C RNA Virus in Response to Lipopolysaccharide: Activity of Lipid-A Portion upon B Lymphocytes¹

From the Immunology Department, Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Washington, District of Columbia 20012 and the Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland, 20014

Abstract

The present studies demonstrate that lipopolysaccharide (LPS) causes the release of endogenous xenotropic type-C RNA virus from BALB/c spleen cells. The evidence suggests that virus release is stimulated by the lipid-A portion of LPS and primarily involves an action of LPS on B lymphocytes. LPS had little or no effect on virus release by T lymphocytes, macrophages, or fibroblasts. These results indicate that the differentiated state of the cell plays an important role in the regulation of endogenous virus release.

Footnotes

¹ This work was supported in part by Contract NCl-E-73-3212 of the Virus Cancer Program of the National Cancer Institute.

² Current address: Department of Medicine, School of Medicine, Allergy and Immunology Section, University of Pennsylvania, Philadelphia, Pennsylvania 19174.

³ Current address: Department of Radiation Therapy, Harvard Medical School, Boston, Massachusetts 02115.