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Genetic Control of the Immune Response to the Ea-2 Alloantigen System of the Mouse

I. The Humoral Antibody Response¹

From the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401

Abstract

The immunization of selected congenic strains and hybrids against the Ea-2.1 cellular alloantigen of the mouse demonstrated that the hamagglutinating antibody response to Ea-2.1 is regulated by a gene or genes associated with the H-2 gene complex. H-2^r and H-2^b are, respectively, responder and non-responder haplotypes.

Footnotes

¹ This investigation was supported by research Grant AI-06525 from the National Institutes of Health, United States Public Health Service.

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