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The Host Antigen Phenomenon in Experimental Murine Schistosomiasis

II. Failure to Demonstrate Destruction of Parasites Transferred from Hamsters to Mice¹

From the Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts 02115

Abstract

Adult Schistosoma mansoni grown in hamsters and transferred directly to the mesenteric vessels of C57BL10J mice previously immunized with hamster cells survive normally despite evidence of cytoxic and hemagglutinating antibodies directed against hamster cells. This finding indicates that species differences may play an important part in the manifestations of the host antigen phenomenon in experimental schistosomiasis.

Footnotes

¹ This study was supported in part by The Wellcome Trust, London and United States Public Health Service Grant AI 12317-01.

² Send all correspondence to: Dr. Markley H. Boyer, Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115.