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Visual Detection of Carcinoembryonic Antigen on Surfaces¹

From the General Electric Corporate Research and Development, Schenectady, New York 12301

Abstract

An attempt is made to detect carcinoembryonic antigen (CEA) at clinically interesting concentrations by using a simple immunologic surface test. Antibodies to CEA are detected in a direct test at concentrations below 1 ng/ml. The sensitivity of this assay is mainly limited by diffusion to the reacting surface. CEA is detected in an inhibition test at concentrations down to 20 ng/ml. The sensitivity of this inhibition test is limited by the average equilibrium constant in solution of the antibody-antigen reaction.

Footnotes

¹ Part of this work was carried out under a contract with the National Cancer Institute.