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The Journal of Immunology, 1976, 116: 696-703.
Copyright © 1976 by The American Association of Immunologists, Inc.
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Effect of Lectins on the Levels of cAMP and cGMP in Guinea Pig Lymphocytes: Early Responses of Lymph Node Cells to Mitogenic and Non-Mitogenic Lectins1

David G. Burleson2 and Harvey J. Sage

From the Veterans Administration Hospital and Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27705

Abstract

Guinea pig lymph node lymphocytes were reacted with two mitogenic lectins (LcL-A or PHA) and two nonmitogenic lectins (AbL or WGA), and the levels of cAMP and cGMP were determined during 30 min of culture. Various concentrations of LcL-A and PHA caused modest (1.5 to 2-fold) rises in cAMP levels. However, the rise in cAMP did not correlate with the degree of mitogenicity. AbL caused a greater rise in cAMP than the mitogenic lectins whereas WGA had no effect on cAMP levels. None of the four lectins causes an appreciable (i.e., greater than 1.5-fold) change in cGMP levels. There does not seem to be any positive correlation between early changes of cAMP and/or cGMP and mitogenesis.

Footnotes

1 This work was supported by Program No. 7665-01 from the Veterans Administration Hospital. Durham, North Carolina and Grant 2 R01 AI 06710-07 ALY from the National Institute of Allergy and Infectious Diseases.

2 David G. Burleson is a captain in the United States Army and was supported by the United States Army long-term carrers program. Taken in part from a thesis submitted by David G. Burleson to Duke University in partial fulfillment of the requirements for the Ph.D. degree in biochemistry, 1975.






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