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Immunity to C-Type RNA Viruses: Antibody Formation after Natural or Deliberate Infection¹

From the Hematology Service, New England Medical Center Hospital, and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111

Abstract

A combined virologic and immunologic study was done in mice that were either naturally or deliberately infected with C-type RNA viruses. In about 60% of B10.A mice, natural infection was accompanied by detectable anti-VEA antibodies in the serum. The absence of such antibodies was a reliable indicator of the absence of virus in B10 mice. Deliberately infected young adult B10 mice failed to eliminate the virus completely, despite high titers of anti-VEA antibodies. B10 mice exposed to B tropic viruses at birth made anti-VEA antibodies but failed to eliminate the virus. By contrast, some NIH Swiss mice exposed to N-tropic virus at birth made anti-VEA antibodies and eliminated the virus.

Footnotes

¹ This research was supported by United States Public Health Service Grants CA 10018 and AM 07937.

² Fellow in Hematology supported by The Netherlands Organization for the Advancement of Pure Research.

³ Fellow in Hematology supported by the Canadian Cancer Society, Inc.