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Resistance to Murine Leukemia in Mice Rejecting Syngeneic Somatic Hybrid Cells¹

From the La Rabida-University of Chicago Institute and the Department of Microbiology, University of Chicago, East 65th Street at Lake Michigan, Chicago, Illinois 60649

Abstract

(A/J x C3H/HeJ) F₁ mice reject somatic cell hybrids of ASL-1 cells (A origin) and LM (TK)^- cells (C3H origin), but die from leukemia within 10 days after the inoculation of approximately 10⁶ viable ASL-1 cells. Mice rejecting hybrid cells survive for prolonged periods after challenge with otherwise lethal numbers of ASL-1 cells. The hybrid cells, rejected by syngeneic F₁ recipients, retained their oncogenic potential as determined by the appearance and progressive growth of tumors in immunologically deficient nu/nu mice injected with the cells. Similar results were obtained using hybrids of a radiation-induced cell line (RADA-1), maintained by serial transfer in strain A mice and LM(TK)^- cells. Syngeneic mice injected with RADA-1 x LM(TK)^- cells failed to form tumors. Mice rejecting RADA-1 x LM(TK)^- hybrid cells survived for prolonged periods after challenge with otherwise lethal numbers of RADA-1 cells.

Footnotes

¹ This work was supported by grants from the National Science Foundation No. GB-40659, the Leukemia Research Foundation, and U.S.P.H.S. 5 P01 CA 14599-03.