HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Carlo, D. J. Articles by Eylar, E. H. Search for Related Content PubMed Articles by Carlo, D. J. Articles by Eylar, E. H.

Experimental Allergic Orchitis and Aspermatogenesis

VI. Transfer of Allergic Orchitis with Immune Cells¹

From the Merck Institute for Therapeutic Research, Rahway, New Jersey 07065, and Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston 29401

Abstract

Typical experimental allergic orchitis (EAO) and aspermatogenesis were successfully transferred to strain 13 guinea pigs with peritoneal exudate and lymph node cells from male and female donor guinea pigs (lacking detectable antibody) previously sensitized with 9 µg of highly purified GP1 glycoprotein isolated from the sperm acrosome. Attempts to transfer the disease with circulating antibody from hyperimmunized animals were not successful. These studies support a cell-mediated basis for the immunopathologic events in EAO.

Footnotes

¹ This is Publication N. 23 from the Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina.

² To whom reprint requests should be addressed: Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, 80 Barre Street, Charleston, South Carolina 29401.