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Antibody in the Sera of Tumor-Bearing Mice that Mediates Spleen Cell Cytotoxicity toward the Autologous Tumor¹

From the Department of Bacteriology and Immunnology, and the Cancer Research Laboratory, University of California, Berkeley, California 94720

Abstract

Pretreatment of MTV-induced BALB/cfC3H mammary tumor cells with autologous serum results in increased spleen cell cytotoxic activity and the recruitment of previously inactive spleen cells to cytotoxic activity against the target cells. These recruiting antibodies are tumor-specific for individual tumors; pretreatment with such serum of target cells of an MTV-induced mammary tumor obtained from a different BALB/cfC3H female results in blocking of spleen cell activity. The autologous recruiting factors are active at dilutions of 1000 or more of whole serum and are found in the 19S fraction after gel filtration.

Footnotes

¹ This work was supported by Public Health Service Research Grant CA-05388 from the National Cancer Institute, and by research funds of the University of California. Part of these studies were performed while the senior author was a Research Professor in the Miller Institute for Basic Research in Science, University of California.

² Present address: Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853.