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Modulation of Help and Suppression in a Hapten-Carrier System¹

From the Department of Bacteriology, University of California, Los Angeles, California 90024

Abstract

Provision of -galactosidase (GZ) under defined conditions of dose and time can either help or suppress a subsequent response to trinitrophenyl (TNP)-GZ in CBA/J mice. The optimal helper effect occurs when 10⁷ spleen cells from mice primed 9 or more days previously with 10 µg GZ are adoptively transferred to irradiated recipients which are then challenged with 10 µg TNP₅₀GZ. Optimum suppression results from the transfer of spleen cells from mice primed 3 days previously with 100 µg GZ and challenge of recipients with TNP₁₅₀GZ. Both help and suppression are carrier-specific and mediated by T cells. In experiments where helper or suppressor cells were mixed with normal cells, the anti-TNP response was proportional to the number of primed cells transferred.

The results point to a wave of suppression as the initial event after immunization, which is succeeded by period in which the helper effect dominates.

Footnotes

¹ This work was supported by Grants AI 11183 from the National Institutes of Health and DRF-819 from the Damon Runyon-Walter Winchell Cancer Fund.