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The Journal of Immunology, 1976, 116: 590-594.
Copyright © 1976 by The American Association of Immunologists, Inc.
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Listeria Cell Wall Fraction: A B Cell Adjuvant1

Priscilla A. Campbell, Carol Schuffler and Gilberto E. Rodriguez2

From the Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Hospital and Research Center, Denver, Colorado 80206

Abstract

A crude cell wall-rich fraction of Listeria monocytogenes (LCWF) has previously been shown to induce resistance to Listeria infection in mice, to be a murine B cell mitogen, and to be an immunologic adjuvant. Data reported here show that LCWF stimulates immune responses by three different murine B cell populations that respond poorly or not at all to thymus-dependent antigens when T cells are severely depleted or absent. These B cell populations include nude mouse spleen cells, anti-{theta} serum-treated spleen cells and bone marrow-derived spleen cells. In addition, sheep erythrocytes coated with LCWF are converted to thymus-independent antigens. The adjuvant effect of LCWF on B cell populations is not enhanced by the presence of T cells, nor does LCWF increase in vivo education of T cells to sheep erythrocyte antigens. Thus, a direct effect of LCWF on T cells could not be demonstrated, suggesting that LCWF does not act on T cells. Because of these LCWF effects on B cells, the possible role of B cells in resistance to infection by Listeria monocytogenes is discussed.

Footnotes

1 This work was supported by United States Public Health Service Grant AI-11240 and Allergy Disease Center Grant No. AI-10398.

2 Present address: Department of Pediatrics. Medical College of Virginia, Richmond, Virginia.






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